This three-year study investigated the safety and efficacy of high-flow oxygen therapy for treating infants with bronchiolitis in settings other than intensive care units (ICU). The research compared the outcomes for hospitalised infants who were randomly assigned to receive either standard oxygen therapy or high-flow oxygen therapy. Infants in the high-flow oxygen group were less likely to require an escalation in their care (12%) compared with those receiving standard oxygen therapy (23%). The research demonstrates that this treatment is safe to use outside ICU and has important implications as bronchiolitis is the most common reason for the hospitalisation of infants world-wide and in under-resourced countries mortality due to bronchiolitis is a serious problem. Having an effective treatment for use outside of ICU will reduce treatment costs.