This paper explores the common, long-standing patterns of social marginalisation and stigmatisation experiences that have uniquely compromised the health, safety and well-being of males from racial/ethnic and sexual minorities. Racial/ethnic and sexual minority males are two of the most persistently unhealthy groups in the United States. In fact, health disadvantages are even more pronounced among groups of boys and men who have not fully enjoyed the socioeconomic power and privilege typically conferred to other males. These are boys and men at the intersections of social identities, communities or groups that have historically been oppressed, marginalised and stigmatised. Moreover, they are boys and men with lived experiences, occupations or material circumstances that disconnect them from day-to-day society. Often, these males have some of the most negative health-related outcomes, including shorter lifespans, more threats to their safety and well-being and less access to health care and social supports. The report also includes recommendations for eliminating health disparities more effectively and ways to improve the overall health and quality of life of these vulnerable boys and men.