This report from the AIHW consolidates the most recently available information on alcohol, tobacco and other drug use in Australia, including key trends in the availability, consumption, harms and treatment for vulnerable populations. It also provides information on a range of health, social and economic impacts of alcohol, tobacco and other drug use. The consumption of alcohol, tobacco and other drugs is a major cause of preventable disease and illness. In Australia, tobacco is the leading cause of cancer, while alcohol was the most common principal drug of concern for clients seeking treatment in 2017-18. As with previous reports, the non-medical use of pharmaceutical drugs continues to be an increasing public health problem in Australia. Self-reported levels of psychological distress were also found to be increasing among recent users of tobacco and illicit drugs.